β‐Cyclodextrin hydrogel incorporating hydrophobically modified poly(N‐isopropylacrylamide) for a temperature‐dependent release |
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Authors: | Mi Sun Lee Jin‐Chul Kim |
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Institution: | Division of Biotechnology and Bioengineering, Institute of Bioscience and Biotechnology, Kangwon National University, 192‐1, Hyoja 2 dong, Chunchon, Kangwon‐do 200‐701, Korea |
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Abstract: | Hydrogels exhibiting a temperature‐dependent release were prepared by incorporating hydrophobically modified poly(N‐isopropylacrylamide) (HmPNIPAM) into β‐cyclodextrin hydrogels (β‐CD hydrogels). The specific loading of HmPNIPAM was about 0.0069 g HmPNIPAM/g β‐CD hydrogels. The incorporation of the polymer was qualitatively conformed by FT‐IR spectroscopy and SEM. The percent release of blue dextran in 24 hr at 20°C (about 77%) was markedly higher than those obtained at 35°C and 45°C (about 53 and 55%, respectively). At the higher temperatures, the volume of the hydrogel could decrease upon the thermal contraction of HmPNIPAM, leading to a smaller mesh and a suppressed release. In fact, the swelling ratio in 24 hr at 35°C and 45°C (about 396% and 405%, respectively) was obviously lower than that obtained at 20°C (about 465%). Copyright © 2011 John Wiley & Sons, Ltd. |
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Keywords: | β ‐cyclodextrin hydrogels poly(N‐isopropylacrylamide) swelling ratio temperature‐dependent release |
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