Study on the Extraction Kinetics of Ketoconazole with Hydroxypropyl‐β‐Cyclodextrin as a Selector

This paper reports on the kinetics of extraction of ketoconazole enantiomers in a Lewis cell, which accompanies by an inclusion reaction. The mass transfer model of the extraction process is established based on the homogeneous reaction mechanism and two‐film theory. Factors such as stirring speed, phase contact area, and ketoconazole concentration are separately investigated. The obtained data show the inclusion reaction is a fast reaction. The reactions have been found to be first order for ketoconazole enantiomers and second order for hydroxypropyl‐β‐cyclodextrin with forward rate constants of 1.716 × 10⁻³ m⁶/(mol²·s) for (−)‐ketoconazole and 2.067 × 10⁻³ m⁶/(mol²·s) for (+)‐ketoconazole.