Diphenylalanine in tetrahydrofuran: a highly potent candidate for the development of novel nanomaterials

The peptide di‐l ‐phenylalanine (FF) has emerged as a highly potent candidate for the development of novel nanomaterials. The unprotected peptide was dissolved in 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP) mixed with tetrahydrofuran (THF) and single crystals of the THF monosolvate, C₁₈H₂₀N₂O₃·C₄H₈O, were grown by slow evaporation in a `vial‐in‐closed‐bottle' system. THF is a molecule that can only act as a hydrogen‐bond acceptor. Thus, the hydrogen‐bond patterns observed in the crystal structures at 100 and 299 K are different compared to that of crystals grown from water and methanol Mason et al. (2014). ACS Nano. 8 , 1243–1253].