Oxidation of L-phenylalanine by diperiodatoargentate(III) in aqueous alkaline medium. A Mechanistic approach |
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Authors: | S D Lamani T M Veeresh S T Nandibewoor |
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Institution: | (1) P.G. Department of Studies in Chemistry, Karnatak University, Dharwad, 580 003, India; |
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Abstract: | The kinetics of oxidation of L-phenylalanine (L-Phe) by diperiodatoargentate(III) (DPA) in alkaline medium at a constant ionic
strength of 0.25 mol/dm−3 has been studied spectrophotometrically. The reaction between DPA and L-phenylalanine in alkaline medium exhibits 1: 1 stoichiometry
(L-phenylalanine: DPA). The reaction shows first order in DPA] and has less than unit order dependence each in both L-Phe]
and Alkali] and retarding effect of IO4−] under the reaction conditions. The active species of DPA is understood to be as monoperiodatoargentate(III) (MPA). The reaction
is shown to proceed via a MPA-L-Phe complex, which decomposes in a rate-determining step to give intermediates followed by
a fast step to give the products. The products were identified by spot and spectroscopic studies. The reaction constants involved
in the different steps of the mechanisms were calculated. The activation parameters with respect to slow step of the mechanism
were computed and discussed. The thermodynamic quantities were also determined for the reaction. |
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