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Synthesis and Reactions of Some New Pyrrolylfuro[2,3‐d]Pyrimidines and Pyrrolopyrazinofuropyrimidines
Authors:SH A Abdel‐Mohsen  SH H Abdel‐Hafez  A A Geies
Abstract:5‐Amino‐4‐methyl‐2‐phenyl‐6‐substitutedfuro2,3‐d]pyrimidines ( 2a‐c ) were reacted with 2,5‐dimethoxytetrahydrfuran to afford the pyrrolyl derivatives 3a‐c . Compound 3a was chosen as intermediate for the synthesis of poly fused heterocycles incorporated furopyrimidines moiety 4–11 . Some of the synthesized compounds were screened for their antibacterial and antifungal activities.
Keywords:Pyrrolylfuro[2  3‐d]pyrimidines  Oxadiazoles  Pyrazines  Thiazoles  Antimicrobial activity
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