Optimization of fast CE analyses of ecstasy derivatives by use of experimental designs |
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Authors: | E Varesio J -Y Gauvrit R Longeray P Lantéri J -L Veuthey |
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Institution: | (1) Laboratoire de Chimie Analytique Pharmaceutique, Université de Genève, 20 bd. d'Yvoy, 1211 Genève 4, Suisse;(2) Laboratoire de Chimiométrie, ESCPE Lyon, Université Claude Bernard Lyon I, Villeurbanne, France |
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Abstract: | Summary The separation by capillary electrophoresis of five ecstasy derivatives has been evaluated by means of experimental designs.
A full-factorial design and a central composite design were employed to optimize the experimental conditions for a fast separation.
With a conventional capillary (62.5 cm length) analytes were separated in less than 8 min. When the capillary length was reduced
the analysis time decreased substantially. Comparisons were made between different procedures (e.g. working at a constant
field or at constant voltage) and finally, a fast separation of five Ecstasy derivatives was achieved in 1 min. |
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Keywords: | Capillary electrophoresis Amphetamines Ecstasy Full-factorial design Central composite design |
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