1-Phenyl-2t-(2-hydroxy-2-propyl)-1r-cyclobutanecarboxamide |
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| Authors: | Gustavo Avila Luis Angel Maldonado Rubén A. Toscano |
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| Affiliation: | (1) División de Estudios de Posgrado, Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán 04510, México, D.F., México;(2) Instituto de Química, Universidad nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Apartado Postal 70-213, México, D.F., México |
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| Abstract: | The cyclobutane ring displays a puckered conformation with the amide group in a perpendicular conformation. An intramolecular hydrogen bond held fixed the orientation of the 2-hydroxy-2-propyl moiety, causing the magnetic non equivalence of methyl groups observed in the room temperature1H-NMR spectrum. Crystal packing reveals the formation of bi-molecular layers parallel to thebc plane. The compound crystallizes in the space groupP21,/c witha=13.351(3),b=7.569(2),c=13.271(3)Å and β=92.03(3)o. Contribution No. 1549 of Instituto de Química, UNAM. |
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| Keywords: | Cyclobutane stereochemistry Stork-Cohen reaction |
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