One step synthesis of 2-substituted 3-tri-(or di-)fluoromethyl-2-propenals in an ionic liquid |
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| Authors: | Tomoya Kitazume Hirokatsu Nagura Shinichi Koguchi |
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| Institution: | Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku Yokohama 226-8501, Japan |
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| Abstract: | Investigation of one step synthesis of 2-substituted 3-tri-(or di-)fluoromethyl-2-propenals has been carried out using versatile aldehydes, tri- or di-fluoroacetaldehyde ethyl hemiacetal in the presence of diethylaminotrimethylsilane (DEATMS) in an ionic liquid, and it was demonstrated that this route enabled us to successfully construct 2-substituted 3-tri-(or di-)fluoromethyl-2-propenals with the high level selectivity of geometric isomers. |
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| Keywords: | 2-Substituted 3-tri-(or di-)fluoromethyl-2-propenals Stereoselectivity One step synthesis |
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