| MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS——A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES |
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| 作者姓名： | JunZhou Yong-zhiQiu Xiao-pengZang Chang-wangPan QiangChen JianShen Si-congLin |
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| 作者单位： | ResearchCenterofSurface＆InterfaceChemistryandEngineeringTechnology,NanjingUniversity,Nanjing210093,China |
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| 基金项目： | This work was financially supported by the Special Funds for Major State Basic Research Projects of China(G1999064705). |
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| 摘 要： | N,N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium (DMMCA) was graft-copolymerized onto the surface of segmented poly(ether urethane) (SPEU) and PE film. The carboxybetaine structure on SPEU and PE film surfaces was confirmed by ATR-FTIR, XPS and water contact angle measurements. Through the experiments with platelet adhesion and protein adhesion assay in vitro, the two materials studied, including poly-DMMCA gel, all show excellent nonthrombogenicity. This confirms once again that the zwitterionic molecular structure on the surfaces of materials is essential for improving their nonthrombogenicity and biocompatibility.
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| 关 键 词： | 生物材料 两性离子 化学结构 羧基三甲铵乙内酯 分子能量 非凝血因子 2-（二甲基氨基）乙基异丁烯酸盐 |
| 收稿时间： | 2003-12-30 |
| 修稿时间： | 2004-03-29 |
MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES |
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| JunZhou Yong-zhiQiu Xiao-pengZang Chang-wangPan QiangChen JianShen Si-congLin.MOLECULAR ENGINEERING STUDIES ON NONTHROMBOGENIC BIOMATERIALS−−A NOVEL CLASS OF NONTHROMBOGENIC BIOMATERIALS WITH ZWITTERIONIC STRUCTURE OF CARBOXYBETAINES[J].Chinese Journal of Polymer Science,2005,0(1):93-102. |
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| Authors: | Jun Zhou Yong-zhi Qiu Xiao-peng Zang Chang-wang Pan Qiang Chen Jian Shen Si-cong Lin |
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| Abstract: | N,N-dimethyl-N-methacryloyloxyethyl-N-carboxyethyl ammonium(DMMCA)was graft-copolymerized onto thesurface of segmented poly(ether urethane)(SPEU)and PE film.The carboxybetaine structure on SPEU and PE filmsurfaces was confirmed by ATR-FTIR,XPS and water contact angle measurements.Through the experiments with plateletadhesion and protein adhesion assay in vitro,the two materials studied,including poly-DMMCA gel,all show excellentnonthrombogenicity.This confirms once again that the zwitterionic molecular structure on the surfaces of materials isessential for improving their nonthrombogenicity and biocompatibility. |
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| Keywords: | Nonthrombogenic biomaterials Zwitterionic biomaterial Carboxybetaine structure Surface graftcopolymerization |
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