Applications of SHAPES screening in drug discovery |
| |
Authors: | Lepre Christopher A Peng Jeffrey Fejzo Jasna Abdul-Manan Norzehan Pocas Jennifer Jacobs Marc Xie Xiaoling Moore Jonathan M |
| |
Affiliation: | Vertex Pharmaceuticals, Incorporated, 130 Waverly Street, Cambridge, MA 02139-4242, USA. lepre@vpharm.com |
| |
Abstract: | The SHAPES strategy combines nuclear magnetic resonance (NMR) screening of a library of small drug-like molecules with a variety of complementary methods, such as virtual screening, high throughput enzymatic assays, combinatorial chemistry, X-ray crystallography, and molecular modeling, in a directed search for new medicinal chemistry leads. In the past few years, the SHAPES strategy has found widespread utility in pharmaceutical research. To illustrate a variety of different implementations of the method, we will focus in this review on recent applications of the SHAPES strategy in several drug discovery programs at Vertex Pharmaceuticals. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|