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Microwave-assisted synthesis of magnetite nanoparticles for MR blood pool contrast agents |
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| Authors: | Wangchuan XiaoHongchen Gu Dan LiDandan Chen Xiaoyong DengZheng Jiao Jiang Lin |
| Affiliation: | a Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China b Department of Radiology, Shanghai Zhongshan Hospital, Shanghai medical college, Fudan University, Shanghai 200032, China c School of Environmental & Chemical Engineering, Shanghai University, Shanghai 201800, China |
| Abstract: | Microwave-assisted polyol process was developed for the synthesis of magnetite nanoparticles with precisely controlled size, high crystallinity and high water solubility. The process is simple, time-saving and low energy-consuming due to the advantages of polyols and microwave irradiation combined. The crystal phases of the nanoparticles were determined by transmission electron microscopy, X-ray powder diffraction and Raman spectrum. The coating materials of the nanoparticles were analyzed by Fourier transformed infrared spectroscopy and thermal gravimetric analysis. Precise size tuning enables an easier way to adjust the relaxation properties of the magnetite nanoparticles. The colloid nanoparticles with high longitudinal relaxivity (r1) and low ratio of transverse relaxivity (r2) to r1 have a potential application in magnetic resonance angiography. |
| Keywords: | Microwave-assisted synthesis Polyol process Magnetite nanoparticle MR blood pool contrast agent |
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