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VISUALIZATION OF ULTRAVIOLET LIGHT-INDUCED THYMINE DIMERS IN DNA BY IMMUNOELECTRON MICROSCOPY |
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| Authors: | Masako U Udono Makoto Hori Michiko Hirayama Hikotaro Yoshida Tadashi Suematsu Takashi Suematsu Toshio Mori Tsukasa Matsunaga Terumi Mizuno Osamu Nikaido |
| Institution: | Department of Dermatology and Electron Microscopy Center, Nagasaki University School of Medicine,1–7–1Sakamoto, Nagasaki 852, Japan;RI Center, Nara Medical University, Kashihara, Nara 634, Japan;Divison of Radiation Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920, Japan |
| Abstract: | Abstract— To see the damage of DNA due to ultravoilet-B more distinctly, immunoelectron microscopic studies using a monoclonal antibody against cyclobutane-type thymine dimers were performed. As a result, we could detect the existence of thymine dimers on human genomic DNA and |
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