Synthesis and characterization of bovine femur bone hydroxyapatite containing silver nanoparticles for the biomedical applications |
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| Authors: | R Nirmala Faheem A Sheikh Muzafar A Kanjwal John Hwa Lee Soo-Jin Park R Navamathavan Hak Yong Kim |
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| Institution: | (1) Bio-Nano System Engineering, College of Engineering, Chonbuk National University, Deokjin-dong 664-14, Jeonju, 561-756, South Korea;(2) Department of Polymer Nano Science and Technology, Chonbuk National University, Jeonju, 561-756, South Korea;(3) College of Veterinary Medicine, Chonbuk National University, Deokjin-dong 664-14, Jeonju, 561-756, South Korea;(4) Department of Organic Materials and Fiber Engineering, Center for Healthcare Technology and Development, Chonbuk National University, Deokjin-dong 664-14, Jeonju, 561-756, South Korea;(5) Semiconductor Materials Processing Laboratory, School of Advanced Materials Engineering, College of Engineering, Chonbuk National University, Deokjin-dong 664-14, Jeonju, 561-756, South Korea; |
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| Abstract: | Bovine femur bone hydroxyapatite (HA) containing silver (Ag) nanoparticles was synthesized by thermal decomposition method
and subsequent reduction of silver nitrate with N,N-dimethylformamide (DMF) in the presence of poly(vinylacetate) (PVAc). The structural, morphological, and chemical properties
of the HA–Ag nanoparticles were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), field-emission
scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS).
TEM images showed that the Ag nanoparticles with size ranging from 8 to 20 nm and were arranged at the periphery of HA crystals.
Bactericidal activity of HA–Ag with different concentration of Ag nanoparticles immobilized on the surface of HA was investigated
against gram-positive Staphylococcus aureus (S. aureus, non-MRSA), Methicillin resistant S. aureus (MRSA) and gram-negative Escherichia coli (E.
coli) by the disc diffusion susceptibility test. The HA–Ag nanoparticles showed that broad spectrum activity against non-MRSA,
MRSA, and E. coli bacterial strains. |
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