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Synthesis of a difunctional orthogonal coupler for the preparation of carbohydrate-functionalized sP(EO-stat-PO) hydrogels |
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| Authors: | Anders Thorsten Adamiak Kathrin Keul Helmut Elling Lothar Möller Martin |
| Institution: | 1. DWI an der RWTH Aachen e.V., and Institute of Technical and Macromolecular Chemistry, RWTH Aachen, Forckenbeckstra?e 50, D‐52056 Aachen, Germany;2. Laboratory for Biomaterials, Institute of Biotechnology and Helmholtz‐Institute for Biomedical Engineering, RWTH Aachen, Worringerweg 1, D‐52056 Aachen, Germany |
| Abstract: | The synthesis and characterization of a new difunctional coupler (4) based on trimethylolpropane (TMP) are described. The coupler is used to connect biologically active N-acetylglucosamine (GlcNAc) on amino-reactive microtiter plates and on star-shaped poly(ethylene oxide)-stat-(propylene oxide)] hydrogel layers in microtiter plates. The biological activity of immobilized carbohydrates is determined using an enzyme-linked lectin assay. |
| Keywords: | biological applications of polymers functionalization of polymers hydrogel coating molecular recognition orthogonal couplers |
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