| Syntheses of amides via iodine-catalyzed multiple sp~3 C–H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides |
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| 基金项目： | supported by the National Natural Science Foundation of China (21272117, 20972068);the Priority Academic Program Development of Jiangsu Higher Education Institutions |
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| 摘 要： | <正>~~
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Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides |
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| Authors: | BingNan Du PeiPei Sun |
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| Institution: | 1. Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210097, China
2. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing, 210023, China
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| Abstract: | The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide (TBHP) as the oxidant, the reaction provided N,N-dialkylamides or N-alkylamides with moderate yields via multiple sp3 C-H bonds activation of methylarenes in aqueous and metal-free conditions. |
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| Keywords: | oxidative coupling iodine-catalyzed methylarenes amides |
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