Efficient synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from simple fluorinated precursors |
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Authors: | Kiss László E Ferreira Humberto S Learmonth David A |
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Affiliation: | BIAL-Portela and Ca, Trofa, Portugal. |
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Abstract: | Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2-(trifluoromethyl)pyridine 1-oxide. |
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