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Synthesis and biological evaluation of novel steroid-linked nitrogen mustards |
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| Authors: | Hua Bing Zhang Ji Jun Xue Xiao Long Zhao De Gang Liu Ying Li State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou PR China |
| Institution: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China |
| Abstract: | Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate la exhibited obvious increasing of activities. |
| Keywords: | Steroid Nitrogen mustards Synthesis Biological activity |
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