On the usage of refined linear models for determiningN-way classification designs which are optimal for comparing test treatments with a standard treatment

Summary In this paper we consider experimental settings in whichv test treatments are to be compared to some control or standard treatment and where heterogeneity needs to be eliminated inn-directions. Using techniques similar to those used by Kunnert (1983,Ann. Statist.,11, 247–257) concerning the determination of optimal designs under a refined linear model, some methods are given for constructingn-way classification designs which areA- andMV-optimal for estimating elementary treatment differences involving the standard treatment fromm-way classification designs,m<n, which areA- andMV-optimal for estimating the same treatment differences. Examples are given for the casen=2 to show how the results obtained can be applied. This research was supported by NSF grant No. DMS-8401943.