Study of the interaction between terazosin and serum albumin: Synchronous fluorescence determination of terazosin |
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Authors: | Chong-Qiu Jiang Ming-Xia GaoJi-Xiang He |
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Institution: | Department of Chemistry, Shandong Normal University, Jinan 250014, China |
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Abstract: | The interactions between terazosin and bovine serum albumin (BSA) were studied by spectrofluorimetry. The binding constants of terazosin with BSA were measured at different temperatures. The effects of various metal ions on the binding constants of terazosin with BSA were also studied. The optimum conditions of synchronous fluorometric determination of terazosin were studied and the method was successfully applied to the determination of terazosin added to serum and urine samples (3σ detection limit 0.21 mg l−1). |
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Keywords: | Terazosin Bovine serum albumin Synchronous fluorescence Determination |
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