The first total synthesis of +-ratjadone |
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Authors: | Bhatt U Christmann M Quitschalle M Claus E Kalesse M |
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Affiliation: | Institut für Organische Chemie der Universit?t Hannover, Schneiderberg 1B, D-30167 Hannover, Germany. |
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Abstract: | The first total synthesis of ratjadone was achieved using a highly convergent approach joining three subunits together with a Wittig olefination and a selective Heck reaction as the pivotal steps. Besides establishing a robust and reliable route for the synthesis of this orphan ligand, the configuration of unknown stereocenters could also be determined. This synthesis not only provides an additional access to a biologically important compound but also enables the synthesis of structural analogues for biological target identification. |
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