Approach to the synthesis of cladiell-11-ene-3,6,7-triol |
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| Authors: | Hutchison John M Lindsay Harriet A Dormi Silvana S Jones Gavin D Vicic David A McIntosh Matthias C |
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| Institution: | University of Arkansas, Fayetteville, Arkansas 72701, USA. |
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| Abstract: | reaction: see text] The synthesis of an advanced intermediate in the synthesis of the title compound has been achieved. Key steps include an Ireland-Claisen rearrangement to install the C7 tertiary alcohol stereocenter, an SN2' reaction of an alkoxymethyl Cu reagent, and a diastereoselective Re-catalyzed allylic alcohol transposition. |
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