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Chemoenzymatic total synthesis of paecilocin A and 3-butyl-7-hydroxyphthalide |
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| Authors: | Ch. Sreelakshmi A. Bhaskar Rao M. Lakshmi Narasu P. Janardhan Reddy B.V. Subba Reddy |
| Affiliation: | 1. Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Institute of Science & Technology, Jawaharlal Nehru Technological University, Hyderabad 500 085, India;3. Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | A highly enantioselective total synthesis of paecilocin A and 3-butyl-7-hydroxyphthalide is described. The key steps involved in this synthesis are enzymatic kinetic resolution and Alder–Rickert reaction. |
| Keywords: | Paecilocin A 3-Butyl-7-hydroxyphthalide Enzymatic kinetic resolution Alder&ndash Rickert reaction |
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