A simple and efficient approach to the synthesis of β-N-methylamino-l-alanine (BMAA) |
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| Authors: | Enzo B Arévalo-García Juan Carlos Colmenares Q |
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| Institution: | 1. Biomedical and Pharmaceutical Sciences Dept., The University of Montana, Missoula, MT 59812, USA;2. Educational Research Institute, Górczewska 8, Warsaw, Poland;3. Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland |
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| Abstract: | A novel, efficient, and straightforward synthesis of β-N-methylamino-l-alanine (BMAA) in two steps starting from l-N,N-dibenzylserine benzyl ester is described. This method, in the light of other syntheses of BMAA, provides benefits such as mild reaction conditions, a simple work-up procedure, good yields, and the retention of the serine stereochemistry. |
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| Keywords: | Serine Benzyl BMAA Amino acid |
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