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A convenient one-pot synthesis of polysubstituted pyrroles from N-protected succinimides |
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| Authors: | Marwan Kobeissi Ogaritte Yazbeck Yamama Chreim |
| Affiliation: | 1. Laboratoire de Synthèse Organique, équipe de Physiotoxicité Environnementale, Lebanese University, Faculty of Sciences, Department of Chemistry, Section V, Lebanon;2. Laboratoire de Synthèse Organique, Lebanese University, Faculty of Sciences, Department of Chemistry, Section I, Hadath, Lebanon;3. Laboratoire de Synthèse Organique, Lebanese University, Faculty of Sciences, Department of Chemistry, Section V, Lebanon |
| Abstract: | The dienamine products formed by the reaction between polysubstituted succinimides and the Petasis reagent were subjected to isomerization under mild acidic conditions to give polysubstituted pyrroles in excellent yields (85–95%). The scope and limitations of this methodology are explored. |
| Keywords: | Dienamines Petasis reagent Methylenation Succinimides Polysubstituted pyrroles |
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