Deuterodehalogenation—a mild method for synthesising deuterated heterocycles期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Deuterodehalogenation—a mild method for synthesising deuterated heterocycles

Authors:	Craig S. Donald Thomas A. MossGary M. Noonan Bryan RobertsEmma C. Durham

Affiliation:	Oncology iMed, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK

Abstract:	We report a mild and efficient method for introducing deuterium into a range of heterocycles by reacting readily available halide analogues in a deuterodehalogenation reaction using D₈-IPA or Et₃SiD under palladium-catalysed conditions.

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