An atom-economic and odorless thia-Michael addition in a deep eutectic solvent |
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Authors: | Najmedin Azizi Zahra YadollahyAmin Rahimzadeh-Oskooee |
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Institution: | Chemistry & Chemical Engineering Research Center of Iran, PO Box 14335-186, Tehran, Iran |
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Abstract: | The first 100% atom-efficient and odorless protocol for carbon–sulfur bond formation in a deep eutectic solvent (DES) as both the reaction medium and catalyst is reported. The biodegradable and inexpensive DES provides an efficient and convenient ionic reaction medium for the thia-Michael addition with in situ generation of S-alkylisothiouronium salts in place of thiols without the urea by-product segment. This protocol offers several advantages including short reaction times, high yields, clean reactions, and inexpensive and commercially available starting materials. |
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Keywords: | Atom economy Deep eutectic solvent Green chemistry Odorless thiol Thia-Michael addition |
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