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The preparation of 3-methyl-4-nitro-5-(2-alkylethenyl)isoxazoles
Authors:Robert Wells  Maria MocciaMauro FA Adamo
Institution:Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, The Royal College of Surgeons in Ireland, 123 St. Stephen’s Green, Dublin 2, Dublin, Ireland
Abstract:We report the first synthetic route to prepare 3-methyl-4-nitro-5-(2-alkylethenyl)isoxazoles in high yields and exclusively as E-diastereoisomers.
Keywords:Michael addition  4-Nitroisoxazoles  Polyfunctional scaffolds  Organocatalysis
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