Lewis acid-catalyzed cascade radical addition/cyclization for the synthesis of 3-substituted isoindolin-1-one derivatives |
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Authors: | Lianjin Zhang Jin Bum KimDoo Ok Jang |
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Affiliation: | Department of Chemistry, Yonsei University, Wonju 220-710, Republic of Korea |
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Abstract: | Radical addition reactions to 2-formylbenzoate-derived hydrazones in the presence of a Lewis acid were developed. Under the reaction conditions, the resulting products were readily converted into 3-substituted isoindolin-1-one derivatives. Diastereoselective synthesis of 3-substituted isoindolin-1-one derivatives was also established employing L-proline as a chiral auxiliary. The cascade radical addition–cyclization reaction allows direct access to 3-substituted isoindolin-1-one derivatives under tin-free conditions. |
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Keywords: | Radical addition Isoindolinone Diastereoselective Lewis acid L-Proline Cascade |
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