Mild addition of carbon nucleophiles to pyridine and quinoline N-oxides under different activation conditions |
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Authors: | Bertrand Lecointre Rabah AzzouzLaurent Bischoff |
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Affiliation: | Normandie Univ, COBRA, UMR 6014 et FR 3038, Univ Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France |
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Abstract: | In the course of our syntheses of functionalised pyridine and quinoline derivatives, we examined the reactivities of pyridine and quinoline N-oxides towards the nucleophilic addition of acidic carbon derivatives. Different activating reagents were used, such as PyBroP, triflic anhydride and a combination of pyrrolidine phosphoramide and triflic anhydride. |
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Keywords: | Pyridine Quinoline N-Oxide C-nucleophiles Coupling agents |
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