BODIPY based ‘click on’ fluorogenic dyes: application in live cell imaging |
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| Authors: | Dinesh Pratapsinh Chauhan Tanmoy Saha Mayurika Lahiri Pinaki Talukdar |
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| Institution: | 1. Department of Chemistry, Mendeleev Block, Indian Institute of Science Education and Research, Pune 411008, India;2. Department of Biology, G1 Block, Indian Institute of Science Education and Research, Pune 411008, India |
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| Abstract: | The design, synthesis, and photophysical properties of new BODIPY-based fluorogenic ‘click on’ dyes are reported. CuAAC reaction of non-fluorescent BODIPY azide with a series of non-fluorescent alkyne molecules resulted in fluorescent triazoles which displayed up to 532-fold enhancement of fluorescence in the red region. Imaging studies confirmed the general trend of cell permeability and a cholesterol linked derivative exhibited selective localization into intracellular membranes. |
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| Keywords: | BODIPY Azide&ndash alkyne click reaction Fluorescence Solvatochromic properties Cell imaging |
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