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Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata |
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| Authors: | Ping-Chung Kuo Yue-Chiun Li Tsong-Long Hwang Guo-Hao Ma Mei-Lin Yang E-Jian Lee Tian-Shung Wu |
| Affiliation: | 1. Department of Biotechnology, National Formosa University, Yunlin 632, Taiwan, ROC;2. Graduate Institute of Natural Products and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan, ROC;3. Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC;4. Neurophysiology Laboratory, Neurosurgical Service, Departments of Surgery and Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University Medical Center and Medical School, Tainan, 701, Taiwan, ROC |
| Abstract: | Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation. |
| Keywords: | Lindera Lauraceae β-Carboline Pictet&ndash Spengler reaction Superoxide anion generation |
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