A convenient synthesis of novel 5-aryl-pyrido[2,3-d]pyrimidines and screening of their preliminary antibacterial properties |
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| Authors: | Lakhinath Saikia Babulal Das Pranjal Bharali Ashim Jyoti Thakur |
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| Affiliation: | 1. Department of Chemical Sciences, Tezpur University (A Central University), Tezpur, Napaam 784028, Assam, India;2. Department of Chemistry, Rajiv Gandhi University (A Central University), Rono Hills, Doimukh 791112, Arunachal Pradesh, India;3. Department of Chemistry, Indian Institute of Technology, Guwahati 781039, Assam, India;4. Department of Molecular Biology and Biotechnology, Tezpur University (A Central University), Tezpur, Napaam 784028, Assam, India |
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| Abstract: | Exploiting the diene nature of 6-[1-aza-2-(dimethylamino)prop-l-enyl]-1,3-dimethyluracil (2), novel 5-aryl-pyrido[2,3-d]pyrimidines (5a–h) have been synthesized. The reaction proceeds through a triene intermediate whose structure has been conclusively established by single crystal X-ray analysis. Role of water is intriguing as the reaction can be stopped at the intermediate stage. Synthesized compounds have been screened for possible antibacterial properties and results showed modest activity. |
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| Keywords: | Uracil Pyrido[2,3-d]pyrimidine Amidine Antibacterial Diels&ndash Alder |
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