Vanadium-catalyzed oxidative Strecker reaction: α-C–H cyanation of para-methoxyphenyl (PMP)-protected primary amines |
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| Authors: | Chen Zhu Ji-Bao XiaChuo Chen |
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| Institution: | Division of Chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, United States |
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| Abstract: | We describe an oxidative Strecker reaction that allows for direct cyanation of para-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension. |
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| Keywords: | Vanadium catalyst C&ndash H cyanation Oxidative Strecker reaction Primary amine Schiff base ligand |
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