Synthesis and neurite outgrowth promoting activity of vibsanin B derivatives |
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| Authors: | Li-Dong Shao Jun Xu Xiu Gao Juan He Yu Zhao Li-Yan Peng Huai-Rong Luo Chengfeng Xia Qin-Shi Zhao |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing 10049, People’s Republic of China |
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| Abstract: | Intramolecular hetero-DA reaction and unexpected retro-aldol like ring opening reaction were performed. As a result, six derivatives with different skeletons of vibsane-type diterpenoids were synthesized from vibsanin B within three steps. Moreover, compounds 2, 3, and 6 enhanced the neurite outgrowth of NGF-mediated PC12 cells. |
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| Keywords: | Intramolecular hetero-DA reaction Retro-aldol like ring opening reaction Vibsanin B Neurite outgrowth promoting |
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