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Pyrrolidine-diaminomethylenemalononitrile organocatalyst for Michael additions of carbonyl compounds to nitroalkenes under solvent-free conditions |
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| Authors: | Kosuke Nakashima Shin-ichi Hirashima Masahiro Kawada Yuji Koseki Norihiro Tada Akichika Itoh Tsuyoshi Miura |
| Institution: | 1. Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan;2. Gifu Pharmaceutical University, 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan |
| Abstract: | The novel pyrrolidine-diaminomethylenemalononitrile organocatalyst 7 promotes the asymmetric conjugate addition of a carbonyl compound to a nitroalkene to afford the corresponding adduct in high yield with up to 99% ee, under solvent-free conditions. |
| Keywords: | Organocatalyst Michael addition Solvent-free Diaminomethylenemalononitrile Nitroalkene |
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