Structure and bioactivity of a trisnorditerpenoid and a diterpenoid from an Okinawan soft coral, Cespitularia sp. |
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| Authors: | Prodip K. Roy Michael C. Roy Junsei Taira Katsuhiro Ueda |
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| Affiliation: | 1. Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-2013, Japan;2. Biological Resources Section, Research Support Division, Okinawa Institute of Science and Technology, Okinawa 904-0495, Japan;3. Department of Bioresources Engineering, Okinawa National College of Technology, Nago-shi, Okinawa 905-2192, Japan |
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| Abstract: | An Okinawan soft coral Cespitularia sp. has proven to be a good source of cytotoxic metabolites having a carbon skeleton of the seco-type variety of xenicin. This soft coral yielded alcyonolide, the major constituent, and other related compounds, all of which have proven to be cytotoxic. Reinvestigation of the cytotoxic ethyl acetate extracts of the coral yielded two new alcyonolide congeners, trisnorditerpenoid 1 and diterpenoid 2, possessing the same carbon skeleton. Their structures were elucidated by a detailed analysis of spectroscopic data (1D, 2D NMR, and MS). Metabolites 1 and 2 showed cytotoxicity against HCT116 cells (IC50 6.04 and 47.0 μM, respectively) and a dose dependent, anti-inflammatory effect in LPS/IFN-γ-stimulated inflammatory RAW 264.7 macrophage cells. |
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| Keywords: | Cespitularia Diterpenoid NMR Cytotoxicity Anti-inflammatory |
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