Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity |
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| Authors: | Mai Akakabe Keiko Kumagai Masayuki Tsuda Yuko Konishi Akira Tominaga Masashi Tsuda Eri Fukushi Jun Kawabata |
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| Institution: | 1. Science Research Center, Kochi University, Kochi 783-8505, Japan;2. Graduate School of Kuroshi Science and Kochi Medical School, Kochi University, Kochi 783-8505, Japan;3. Center for Advanced Marine Core Research, Kochi University, Kochi 783-8502, Japan;4. Research Faculty of Agriculture, Hokkaido University, Sapporo, Hokkaido 060-8589, Japan |
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| Abstract: | A novel linear polyketide, amphirionin-5 (1), has been isolated from the cultivated algal cells of the benthic dinoflagellate Amphidinium sp. (strain KCA09053), and the structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data. Amphirionin-5 (1) resulted in a 282% increase in the proliferation of murine bone-marrow derived stromal ST-2 cells and 320% increase in the proliferation of murine osteoblastic MC3T3-E1 cells. |
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| Keywords: | Polyketide Dinoflagellate Amphidinium Cell-proliferation promoting activity |
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