An expeditious approach to access 2-arylimidazo[1,2-a]pyridin-3-ol from 2-amino pyridine through a novel Petasis based cascade reaction |
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| Authors: | Yuanxiang Wang Biswajit Saha Fang Li Brendan FrettHong-yu Li |
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| Institution: | College of Pharmacy, Department of Pharmacology and Toxicology, The University of Arizona, Tucson, USA; BIO-5 Oro Valley, The University of Arizona, Ora Valley, AZ 85737, USA |
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| Abstract: | An expeditious cascade protocol for the synthesis of functionalized imidazo1,2-a]pyridin-3-ols was developed based on the Petasis reaction. With the availability of commercial reagents and high efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of imidazo-pyridin-3-ol analogues. |
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| Keywords: | Cascade reaction Petasis reaction MCR 2-Arylimidazo[1 2-a]pyridine-3-ol |
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