A rapid,highly efficient,and general protocol for the synthesis of functionalized triarylmethanes: a straightforward access for the synthesis of (−)-tatarinoid C |
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| Authors: | B Madhu Babu Pramod B ThakurN Nageswara Rao G Santosh KumarHM Meshram |
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| Institution: | Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A rapid, efficient, and convenient synthesis of functionalized triarylmethane is described by the Friedel–Crafts alkylation of methoxybenzenes with a variety of aldehydes in the presence of BF3·OEt2. The generality of the method is demonstrated by screening a variety of di- or tri-substituted arenes as well as substituted aromatic, heteroaromatic, and aliphatic aldehydes. (−)-Tatarinoid C is synthesized in a single step following the same protocol. |
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| Keywords: | Triarylmethanes Friedel&ndash Crafts reaction (&minus )-Tatarinoid C BF3· OEt2 Rapid synthesis |
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