Efficient synthesis of novel tricyclic fused pyranothiazolopyrimidine derivatives via isocyanide-based three-component reactions |
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| Authors: | Mahdieh Zangouei Abbas Ali Esmaeili Azizolah Habibi Ali Reza Fakhari |
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| Affiliation: | 1. Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran;2. Faculty of Chemistry, Kharazmi University, No. 49, Mofateh Ave., Tehran, Iran;3. Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, G.C., PO Box 19396-4716, Evin, Tehran, Iran |
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| Abstract: | An efficient and facile one-pot synthesis is described for the preparation of novel tricyclic fused pyranothiazolopyrimidines containing both biologically active thiazolopyrimidine and pyranopyrimidine templates via three-component reaction involving an isocyanide with a dialkylacetylenedicarboxylate (DAAD) and 2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-5,7(6H)-dione, in high yields. |
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| Keywords: | Multi-component reaction Pyranothiazolopyrimidine Dialkylacetylenedicarboxylates Alkyl isocyanide One-pot synthesis |
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