Copper-mediated oxidative tandem reactions with molecular oxygen: synthesis of 2-arylbenzoxazinone derivatives from indoles |
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| Authors: | Mitsuaki Yamashita Akira Iida |
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| Institution: | School of Agriculture, Kinki University, Nakamachi, Nara 631-8505, Japan |
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| Abstract: | We developed an efficient method for the transformation of indoles by utilizing a copper catalyst and molecular oxygen as the oxidant. The transformation involves a tandem oxidative process of 2-arylindoles. Our reaction afforded a variety of N-benzoyl anthranilic acids and benzoxazinones. Our investigation revealed that the choice of solvent and additives is critical in these reactions. |
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| Keywords: | Copper Oxidation Rearrangement Indoles |
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