Marine bacterial inhibitors from the sponge-derived fungus Aspergillus sp. |
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| Authors: | Yaming Zhou Abdessamad Debbab Victor Wray WenHan Lin Barbara Schulz Rozenn Trepos Claire Pile Claire Hellio Peter Proksch Amal H. Aly |
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| Affiliation: | 1. Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, D-40225 Düsseldorf, Germany;2. Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany;3. National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, 100083 Beijing, People’s Republic of China;4. Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, D-31806 Braunschweig, Germany;5. School of Biological Sciences, King Henry 1st Street, University of Portsmouth, Portsmouth PO1 2DY, UK |
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| Abstract: | Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated from the Mediterranean sponge Tethya aurantium, yielded a new tryptophan derived alkaloid, 3-((1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindolin-3-yl)methyl)-1-methyl-3,4-dihydrobenzo[e][1,4]diazepine-2,5-dione (1), and a new meroterpenoid, austalide R (2), together with three known compounds (3–5). The structures of the new compounds were unambiguously elucidated on the basis of extensive one and two-dimensional NMR (1H, 13C, COSY, HMBC, and ROESY) and mass spectral analysis. Interestingly, the compounds exhibited antibacterial activity when tested against a panel of marine bacteria, with 1 selectively inhibiting Vibrio species and 2 showing a broad spectrum of activity. In contrast, no significant activity was observed against terrestrial bacterial strains and the murine cancer cell line L5178Y. |
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| Keywords: | Aspergillus Marine natural products Sponge-derived fungi Tethya aurantium |
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