An efficient synthesis of conjugated 5-aryl-1,3,4-oxadiazoles from 3-heteroarylacrylohydrazides and acid chlorides |
| |
| Authors: | Agnieszka Kudelko Monika Wróblowska |
| |
| Institution: | Department of Chemical Organic Technology and Petrochemistry, The Silesian University of Technology, Krzywoustego 4, PL-44100 Gliwice, Poland |
| |
| Abstract: | New derivatives of 5-aryl-2-2-(2-furyl)ethenyl]-1,3,4-oxadiazoles and 5-aryl-2-2-(2-thienyl)ethenyl]-1,3,4-oxadiazoles are synthesized in a stepwise procedure through intermediate acyclic N′-arylcarbonyl-N-2-(2-heteroaryl)acryloyl]hydrazines, starting from 3-(2-heteroaryl)acrylic acid hydrazides and acid chlorides. A facile one-pot methodology leading to the final 1,3,4-oxadiazoles is also described. |
| |
| Keywords: | Cyclization Heterocycles 1 3 4-Oxadiazoles 3-Heteroarylacryloylhydrazide |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
