Angumycinones A and B,two new angucyclic quinones from Streptomyces sp. KMC004 isolated from acidic mine drainage |
| |
Authors: | Hyun Bong Park Jae Kyun Lee Kang Ro Lee Hak Cheol Kwon |
| |
Institution: | 1. Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea;2. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea;3. Korea Institute of Science and Technology, PO Box 131, Cheongyang, Seoul 130-650, Republic of Korea |
| |
Abstract: | Two new angucyclic quinones, angumycinones A (1) and B (2) and six known angucyclinone analogues (3–8) were isolated from a liquid culture extract of the Streptomyces sp. KMC004 strain from acidic coal mine drainage. The structures of these compounds were established using extensive spectroscopic data analyses, including NMR, HRFABMS, UV, CD, and X-ray crystallography. Compounds 1–8 were tested for antimicrobial activity against ten pathogenic microbial or fungal strains. Angumycinone B (2) exhibited antimicrobial activity against Micrococcus luteus, Enterococcus hirae, and methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration values of 0.78, 1.56, and 12.5 μg/mL, respectively. |
| |
Keywords: | Streptomyces Angucyclinone Angumycinone Acidic mine drainage |
本文献已被 ScienceDirect 等数据库收录! |
|