Stereoselective total synthesis of the (Z)-isomer of a novel phytotoxic nonenolide from Phomopsis sp. HCCB03520 and its C-6 epimer |
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| Authors: | Cheruku Ravindra Reddy Biswanath Das |
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| Institution: | Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India |
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| Abstract: | The (Z)-isomer of a phytotoxic nonenolide, (6S,7R,9R)-6,7-dihydroxy-9-propylnon-4-eno-9-lactone isolated from Phomopsis sp. HCCB03520 and its C-6 epimer have been synthesized through a common route starting from butyraldehyde. The synthesis involves enantioselective Maruoka allylation, Sharpless asymmetric epoxidation and intramolecular ring closing metathesis as the important steps. |
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| Keywords: | Phytotoxic nonenolide (6S 7R 9R)-6 7-Dihydroxy-9-propylnon-4-eno-9-lactone (Z)-Isomer C-6 epimer Total synthesis Common route |
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