Regiospecific strategies for the synthesis of novel dihydropyrimidinones and pyrimidopyridazines catalyzed by molybdate sulfuric acid |
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| Authors: | Bahador Karami Saeed Khodabakhshi Sedigheh Akrami Mahnaz Farahi |
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| Affiliation: | 1. Department of Chemistry, Yasouj University, Yasouj 75918-74831, Iran;2. Nanotechnology Research Center, Research Institute of Petroleum Industry, Tehran, Iran |
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| Abstract: | The one-pot reactions of aryl glyoxals with acetylacetone and urea using molybdate sulfuric acid (5 mol %) lead to the novel functionalized 5-acetyl-4-(aryloyl)-3,4-dihydropyrimidinones, which readily undergo the Knorr condensation with hydrazines to produce new pyrimido[4,5-d]pyridazines. The present strategies are in accordance with green chemistry principles through the use of a safe and recyclable catalyst under solvent-free conditions. |
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| Keywords: | Aryl glyoxal Pyrimido[4,5-d]pyridazines Hydrazine |
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