Microwave-mediated synthesis of N-methyliminodiacetic acid (MIDA) boronates |
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| Authors: | Adam J Close Paul Kemmitt Matthew K Emmerson John Spencer |
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| Institution: | 1. Dept of Chemistry, School of Life Sciences, University of Sussex, Falmer, BN1 9QJ, UK;2. AstraZeneca, Mereside Alderley Park, Macclesfield, SK10 4TG, UK |
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| Abstract: | A library of over 20, mainly aryl or heteroaryl, N-methyliminodiacetic acid (MIDA) boronates have been synthesised. A rapid microwave-mediated (MW) method (5–10 min) has been developed using polyethylene glycol 300 (PEG 300) as solvent. However, acetonitrile (MeCN) and dimethylformamide (DMF) were found to be alternative solvents, the latter especially for 2-substituted aryl boronic acids. |
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| Keywords: | Boron chemistry Microwaves Green chemistry |
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