Efficient and selective hydration of nitriles to amides in aqueous systems with Ru(II)-phosphaurotropine catalysts |
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| Authors: | Evelin Bolyog-Nagy Antal Udvardy Ferenc Joó Ágnes Kathó |
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| Institution: | 1. Department of Physical Chemistry, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary;2. MTA-DE Homogeneous Catalysis and Reaction Mechanisms Research Group, Debrecen, Egyetem tér 1, H-4032, Hungary |
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| Abstract: | A simple and efficient synthesis of amides by selective hydration of aromatic and aliphatic nitriles is described. The catalysts are prepared in situ from easily available Ru-precursors and ligands using water as the solvent. The most active catalyst, is obtained from RuCl2(dmso)4] and benzylated 1,3,5-triaza-7-phosphaadamantane. Of the 16 substrates examined, 92–99% conversions of 14 nitriles were achieved in one hour at reflux temperature. |
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| Keywords: | Nitrile hydration Ruthenium Phosphine Amides |
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