An efficient and green synthesis of phthalide-fused pyrazole and pyrimidine derivatives |
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Authors: | Anahita Motamedi Elahe SattariPeiman Mirzaei Mahsa ArmaghanAyoob Bazgir |
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Institution: | Department of Chemistry, Shahid Beheshti University G.C., Tehran 1983963113, Iran |
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Abstract: | An efficient and green method for the synthesis of phthalide isobenzofuran-1(3H)-one] fused pyrazoles via the catalyst-free condensation reaction of 2-formylbenzoic acid, hydrazine hydrate, and acetylenic esters in water is reported. Reaction of 2-formylbenzoic acid with 6-amino-uracils or cyclic 1,3-diketones resulted in the formation of phthalide-fused pyrimidine or cyclic 1,3-diketone derivatives. |
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Keywords: | Uracil Phthalide Pyrimidine Pyrazole Green chemistry |
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