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Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives as novel anticancer nucleoside analogs |
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| Authors: | Marc A Labroli Michael P Dwyer Ruichao Shen Janeta Popovici-Muller Qinglin Pu Judson Richard Kristen Rosner Kamil Paruch Timothy J Guzi |
| Institution: | 1. Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA;2. Merck Research Laboratories, PO Box 2000, 126 E. Lincoln, Rahway, NJ 07065, USA;3. Merck Research Laboratories, 33 Louis Pasteur Avenue, BMB-3, Boston, MA 02115, USA |
| Abstract: | A novel class of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either SN2 displacement or reductive amination to provide the desired derivatives. |
| Keywords: | Nucleoside Gemcitabine Reductive amination Anticancer |
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